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pentobarbital will reduce the level or impact of fedratinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Outcome of coadministering a robust CYP3A4 inducer with fedratinib has not been researched.pentobarbital will minimize the level or impact of bexarotene by impacting hepatic/intestinal enzyme CYP3A4 me